(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
CAS: 104992-55-4
Molecular Formula: C53H66N7O8PSi
(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite - Names and Identifiers
| Name | N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite |
| Synonyms | Bz-rA Phosphoramidite 2'-TBDMS-rA(N-Bz) Phosphoramidite 2'-TBDMS -Bz-rA-CE-Phosphoramidite 5'-O-DMT-2'-TBDMS-rA(N-Bz)-3'-CEDPA DMT-2′O-TBDMS-rA(bz) Phosphoramidite 5'-DMT-2'-O-TBDMS- N6-Benzoyl-Adenosine Phosphoramidite N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite 5'-O-(4,4'-DiMethoxy)-N6-benzoyl-2'-O-(t-butyl diMethylsilyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite |
| CAS | 104992-55-4 |
| EINECS | 2017-001-1 |
| InChIKey | FFXHNCNNHASXCT-RFMFGJHUSA-N |
(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite - Physico-chemical Properties
| Molecular Formula | C53H66N7O8PSi |
| Molar Mass | 988.19 |
| Appearance | powder |
| Color | white to off-white |
| pKa | 7.87±0.43(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| MDL | MFCD00080297 |
(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29349990 |
(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite - Introduction
N-benzoyl-5 '-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl) dimethylsilyl] adenosine -3 '-(2-cyanoethyl-N,N-Diisopropyl) phosphoramidite is an organic compound, the following is an introduction to its properties, uses, synthesis methods and safety information:
Nature:
1. Appearance: colorless to light yellow solid
2. molecular formula: C49H52N7O6P
3. Molecular weight: 879.95g/mol
4. Melting point:>200°C
5. Solubility: Soluble in polar organic solvents such as methanol, chloroform and dichloromethane
Use:
N-benzoyl-5 '-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl) dimethylsilyl] adenosine -3 '-(2-cyanoethyl-N,N-diisopropyl) phosphoramidite is an important organic synthesis intermediate with potential applications in the field of biomedicine. It can be used in the synthesis of nucleosides, such as RNA and DNA precursor molecules, and in the preparation of antiviral and anticancer drugs. In addition, due to the presence of its phosphoramide group, it can also be used as a catalyst for nucleic acid modification and reactions.
Preparation Method:
The synthesis method of N-benzoyl -5 '-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl) dimethylsilyl] adenosine -3 '-(2-cyanoethyl-N,N-diisopropyl) phosphoramidite is complicated, and it is generally synthesized step by step through multi-step reaction. The specific preparation steps are relatively long, and appropriate intermediates and reagents need to be used. At the same time, attention should be paid to reaction control and condition optimization.
Safety Information:
Because N-benzoyl-5 '-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl) dimethylsilyl] adenosine -3 '-(2-cyanoethyl-N,N-diisopropyl) phosphoramidite has not been specifically reported, the safety of this compound is not known. However, as an organophosphoryl compound, it may have certain toxicity and irritation. During use or operation, strict safety procedures should be followed, including wearing appropriate personal protective equipment, avoiding direct contact with skin and eyes, and operating under well-ventilated conditions as much as possible. At the same time, the research results of similar compounds and relevant safety data can be referenced to evaluate their potential hazards and protective measures requirements. If you need to use this compound, please do it under the guidance of professionals and ensure that relevant regulations and standards are followed.
Nature:
1. Appearance: colorless to light yellow solid
2. molecular formula: C49H52N7O6P
3. Molecular weight: 879.95g/mol
4. Melting point:>200°C
5. Solubility: Soluble in polar organic solvents such as methanol, chloroform and dichloromethane
Use:
N-benzoyl-5 '-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl) dimethylsilyl] adenosine -3 '-(2-cyanoethyl-N,N-diisopropyl) phosphoramidite is an important organic synthesis intermediate with potential applications in the field of biomedicine. It can be used in the synthesis of nucleosides, such as RNA and DNA precursor molecules, and in the preparation of antiviral and anticancer drugs. In addition, due to the presence of its phosphoramide group, it can also be used as a catalyst for nucleic acid modification and reactions.
Preparation Method:
The synthesis method of N-benzoyl -5 '-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl) dimethylsilyl] adenosine -3 '-(2-cyanoethyl-N,N-diisopropyl) phosphoramidite is complicated, and it is generally synthesized step by step through multi-step reaction. The specific preparation steps are relatively long, and appropriate intermediates and reagents need to be used. At the same time, attention should be paid to reaction control and condition optimization.
Safety Information:
Because N-benzoyl-5 '-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl) dimethylsilyl] adenosine -3 '-(2-cyanoethyl-N,N-diisopropyl) phosphoramidite has not been specifically reported, the safety of this compound is not known. However, as an organophosphoryl compound, it may have certain toxicity and irritation. During use or operation, strict safety procedures should be followed, including wearing appropriate personal protective equipment, avoiding direct contact with skin and eyes, and operating under well-ventilated conditions as much as possible. At the same time, the research results of similar compounds and relevant safety data can be referenced to evaluate their potential hazards and protective measures requirements. If you need to use this compound, please do it under the guidance of professionals and ensure that relevant regulations and standards are followed.
Last Update：2024-04-09 21:11:58
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite Request for quotationCAS: 104992-55-4
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
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